Reply: Cure Not Possible, by Definition

Amyloidosis: is a cure possible?

The amyloidoses are protein misfolding diseases in which different soluble proteins aggregate as extracellular insoluble fibrils. This process causes organ dysfunction and death, unless it is arrested by therapy. So far, 25 types of amyloidosis have been classified according to the protein forming the amyloid deposits. In AL amyloidosis, a usually small-sized bone marrow plasma cell clone produ...

Definition of cure for Hodgkin's disease.

with Stage I and II disease there is excessive mortality per unit time as compared to the control population for at least 10 years after treatment. Thus, while the above definition is acceptable, the lag period required for the evaluation of potentially curative treatment is very long. In an attempt to determine the presence and degree of curative treatment in a shorter time, the relapse-free i...

New treatments in myeloma--is cure possible?

Myeloma is a malignancy of the plasma cells derived from the B lymphocyte series. It is characterized by early and wide dissemination of tumour cells resulting in bone destruction, anaemia, infections, hypercalcaemia, renal failure and occasionally symptoms of hyperviscosity. The myeloma cells may either produce local destruction ofbone or produce paraprotein ('M' band in the serum), or the lig...

Cancer: Relief of Pain and Possible Cure

Reply to “(Im)Possible Frontiers: A Comment”

In Brennan and Lo (2010), a mean-variance efficient frontier is defined as “impossible” if every portfolio on that frontier has negative weights, which is incompatible with the Capital Asset Pricing Model (CAPM) requirement that the market portfolio is mean-variance efficient. We prove that as the number of assets n grows, the probability that a randomly chosen frontier is impossible tends to o...